Evolence Injections

Evolence, an injectable cosmetic filler, was approved by the FDA in June 2008 for the correction of facial wrinkles and folds. Intended to correct deep facial lines such as those extending from the corners of the mouth to the nose. It is derived from porcine (pig) collagen. Representing a new generation of injectable fillers, the patented technology behind Evolence uses natural sugars to link the collagen molecules, creating a structural framework around which the body can add its own naturally produced collagen.

Although it showed earlier promise, manufacturer Johnson & Johnson stopped advertising this treatment in November 2009, reportedly because it was no longer competitive with other dermal fillers such as Botox Cosmetic, Artefill and Restylane injections.  While no longer sold in the United States, it may still be available in other countries, including Canada, Israel, and some European locations.

Are You a Good Candidate?

Candidates for Evolence are adults who are looking to erase the signs of aging. It works best on deep wrinkles, rather than shallow lines such as ‘crow’s feet’ around the eyes. Your doctor can help you determine which dermal filler is appropriate to achieve your desired results.

You should not undergo this treatment if you have a history of allergic reactions or sensitivity to collagen products or pig products. Bleeding disorders and certain other medical conditions or medications can make you a poor candidate. Because it is made from pig tissue, some Jewish, Islamic, and vegetarian patients may not wish to use this product.


Evolence consists of an opaque gel with a yellowish hue. It is injected into the deeper layers of the skin, in order to fill out moderate to severe facial wrinkles and folds. Once injected, the pig collagen binds with the body’s own supply of collagen, a key structural element within the skin. As a result, the injection makes the skin stronger and increases its volume filling in facial wrinkles from inside the body.

To inject, the doctor may first apply a topical numbing cream or local anesthetic. Then, a pre-filled syringe is used to deliver the solution into the deeper layers of the skin, targeting deep facial folds. The entire procedure takes under an hour and patients are free to continue their normal daily routine immediately.

Complications & Risks

Potential risks include infection and bleeding. Other possible complications include lumps or firmness under the skin at the treated site, which may be noticeable when the skin is pressed. These are usually less than one centimeter in diameter, and may occur with delayed onset following the use of Evolence. This risk may have played a role in Johnson & Johnson’s decision to stop marketing the product in 2009. At the time, several dermatologists explained that Evolence has a stiffer formulation than other dermal fillers. As a result, there is an increased likelihood that the injected material will form clumps under the skin, giving a lumpy appearance.

Recovery Time

There is no downtime with this procedure; most patients return to work and other daily activities immediately. Side effects include mild swelling, redness, and discomfort around the injection site, lasting a few hours or days. The results of Evolence are expected to last for six to twelve months.

Price of Evolence Injections

While no longer offered in the United States, Evolence injections cost between $500 to $700 per syringe. Learn about the price of other dermal fillers such as the cost of Radiesse or Dysport treatments to help reduce the appearance of fine lines and wrinkles.


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