Glaucoma

Glaucoma is a group of eye diseases where the optic nerve has been damaged by high pressure within the eye. It is one of the leading causes of blindness in people 60 or older. (1) While it is more common in older adults, it can occur at any age.

What causes glaucoma?

Glaucoma is caused by elevated eye pressure, or intraocular pressure (IOP), due to fluid buildup in the eye. Normally, this fluid drains through a specialized tissue, called the trabecular meshwork, at the angle where the cornea and iris meet. Sometimes, this drainage system is blocked, or your eye makes too much fluid, which increases IOP. As this pressure continues to build, the optic nerve may be damaged, leading to vision loss in that eye.

Types of glaucoma

There are two main types of glaucoma that can develop: open-angle (chronic) glaucoma, and angle-closure (acute) glaucoma. In addition, there are variations of glaucoma that can develop. (2)

Open-Angle (Chronic) Glaucoma

Open-angle glaucoma is the most commonly diagnosed form. In this type, the trabecular meshwork is partially blocked, preventing fluid from draining out of the eye. This causes pressure to gradually build up, damaging the optic nerve. Symptoms include:

  • Blind spots in your peripheral or central vision; may be in one or both eyes
  • Tunnel vision that develops in advanced stages

Angle-Closure (Acute) Glaucoma

Angle-closure glaucoma, also known as closed-angle glaucoma, forms when the iris bulges forward and blocks the drainage angle between the cornea and iris. Fluid will not circulate through the eye properly, and the pressure increases. In some cases, a patient may have a narrow drainage angle, making them more susceptible to angle-closure glaucoma. Symptoms include:

  • Eye pain and redness
  • Nausea and/or vomiting
  • Severe headache
  • Blurred vision
  • Halos forming around lights

Normal Tension Glaucoma

Normal tension glaucoma (also known as low-tension or normal-pressure glaucoma) occurs when there is damage to the optic nerve with no increase in IOP. Your risk of developing normal tension glaucoma increases if you have a family history of the condition, are of Japanese ancestry, or have a history of systemic heart disease. The exact causes are still unknown. (3)

Congenital Glaucoma

Congenital glaucoma develops in infants and children and is caused by defects in the eye’s drainage system. These defects lead to fluid buildup and increased IOP, which damages the optic nerve. This is a rare condition that can be passed down through family and is usually treated through surgery and medication. (4)

Secondary Glaucoma

Secondary glaucoma often occurs as a side effect of eye injury, inflammation, advanced cases of diabetes or cataracts, or use of steroids. In rare cases, it can develop after eye surgery. Treatments for secondary glaucoma can vary depending on the underlying cause, but usually include a combination of surgery and medication. (5)

Risk factors for developing glaucoma

Glaucoma can occur in anyone, but there are risk factors that increase your chances of developing it. These can include:

  • Increased age (60 years or older)
  • Diabetes
  • High blood pressure
  • Long-term steroid use, such as corticosteroid eye drops
  • Being extremely farsighted or nearsighted
  • Previous eye injuries or surgeries

Familial risk factors also contribute to your chances of developing glaucoma. If a member of your family has had glaucoma, your chances of developing it increase. If you are of Black, Asian, or Hispanic descent, your chances also increase.

Diagnosing

In order to diagnose glaucoma, your ophthalmologist will perform a comprehensive medical and eye examination. The following tests and procedures may be performed: (6)

  • Detailed medical history: Your doctor will ask you about your currently medical conditions, especially if they may impact your eye health (diabetes, high blood pressure, etc.) They will also want to know the symptoms you’re experiencing, and if anyone in your family has a history of glaucoma.
  • Tonometry: This exam is used to measure your IOP. With your eye numbed, your doctor will use a tonometer to gently apply pressure to the eye. Normal eye pressure ranges from 12-22 mm Hg; glaucoma is diagnosed when eye pressure exceeds 20 mm Hg.
  • Ophthalmoscopy: During this procedure, your doctor uses a small device with a light to look at your optic nerve for possible damage.
  • Gonioscopy: This exam is used to look at the angle where the iris meets the cornea in your eye. This is used to diagnose angle-closure glaucoma (narrow and closed angle), or open-angle glaucoma (wide and open angle).
  • Perimetry: This test is used to help your doctor determine if your vision has been impacted by glaucoma by measuring your central and peripheral (side) vision.
  • Pachymetry: This exam is used to measure the thickness of your cornea. People with thin corneas are at an increased risk of developing glaucoma.

Glaucoma treatments

If you are diagnosed with a form of glaucoma, it is important to receive immediate treatment to prevent any more damage from occurring to the optic nerve. Signs and symptoms will vary depending on the type and stage of the condition.

Unfortunately, there are no treatments available to cure glaucoma. Instead, your doctor will focus on stabilizing your eye pressure to prevent further damage to vision.

Laser-Based and Surgical Treatments

If your glaucoma is caused by a blockage in your eye, your doctor may suggest surgery as a treatment option. These procedures, performed either as laser-based treatments or as surgery, will make a path in the eye’s drainage system for fluid to flow through. (7, 8)

Angle-closure glaucoma is treated as a medical emergency and requires treatment to reduce IOP immediately. A laser peripheral iridotomy may be performed to increase fluid movement in the eye. This procedure works by creating small holes in the iris, allowing fluid to flow through the drainage angle. (8)

Medications

Medications are also used to help control and reduce IOP. Eyedrops are used daily to control eye pressure. These contain a number of drugs that work to limit fluid production, or help it drain from the eye better. (9)

Oral medications are also available if eyedrops are not effective enough alone. This is typically a carbonic anhydrase inhibitor that works by limiting fluid production in the eye. (1)

Can glaucoma be prevented?

Unfortunately, glaucoma can’t be prevented, and vision loss due to glaucoma can’t be restored. Be sure to visit your eye doctor annually for your preventive eye exam. Routine tests performed during these exams may identify optic nerve damage and other eye issues before they become more serious. The earlier glaucoma is recognized, the earlier treatment can begin.